Axonal release sites discovered
نویسندگان
چکیده
منابع مشابه
Mitochondrial Ultrastructure Is Coupled to Synaptic Performance at Axonal Release Sites
Mitochondrial function in neurons is tightly linked with metabolic and signaling mechanisms that ultimately determine neuronal performance. The subcellular distribution of these organelles is dynamically regulated as they are directed to axonal release sites on demand, but whether mitochondrial internal ultrastructure and molecular properties would reflect the actual performance requirements in...
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Oxytocin produces anxiolytic effects via the central nucleus of the amygdala but how the peptide reaches its receptors in this region has been unclear. In this issue of Neuron, Knobloch et al. (2012) demonstrate that evoked oxytocin release from axon terminals within the central amygdala results in attenuation of fear.
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Although drugs used to treat several neurological diseases are presumed to target synapses that secrete dopamine (DA), relatively little is known about synaptic vesicle (SV) release mechanisms at single DA synapses. We found that the relative probability of release (Pr) varied between individual DA synapses. Furthermore, DA terminals generally exhibited lower Pr than glutamatergic hippocampal (...
متن کاملCytochrome c release and caspase activation in traumatic axonal injury.
Axonal injury is a feature of traumatic brain injury (TBI) contributing to both morbidity and mortality. The traumatic axon injury (TAI) results from focal perturbations of the axolemma, allowing for calcium influx triggering local intraaxonal cytoskeletal and mitochondrial damage. This mitochondrial damage has been posited to cause local bioenergetic failure, leading to axonal failure and disc...
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Ca(2)(+)-dependent activator protein for secretion 2 (CAPS2 or CADPS2) potently promotes the release of brain-derived neurotrophic factor (BDNF). A rare splicing form of CAPS2 with deletion of exon3 (dex3) was identified to be overrepresented in some patients with autism. Here, we generated Caps2-dex3 mice and verified a severe impairment in axonal Caps2-dex3 localization, contributing to a red...
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ژورنال
عنوان ژورنال: Nature Reviews Neuroscience
سال: 2007
ISSN: 1471-003X,1471-0048
DOI: 10.1038/nrn2114